| ProductName: | HumanSonicHedgehog(SHH)recombinantproteincarrier-free |
| Description: | Sonichedgehoghomolog(SHH)isoneofthreeproteinsinthemammaliansignalingpathwayfamilycalledhedgehog,theothersbeingdeserthedgehog(DHH)andIndianhedgehog(IHH).SHHisthebeststudiedligandofthehedgehogsignalingpathway.Itplaysakeyroleinregulatingvertebrateorganogenesis,suchasinthegrowthofdigitsonlimbsandorganizationofthebrain.SonichedgehogisthebestestablishedexampleofamorphogenasdefinedbyLewisWolpert"sFrenchflagmodel—amoleculethatdiffusestoformaconcentrationgrADIentandhasdifferenteffectsonthecellsofthedevelopingembryodependingonitsconcentration.SHHremainsimportantintheadult.Itcontrolscelldivisionofadultstemcellsandhasbeenimplicatedindevelopmentofsomecancers.RecombinantSonicHedgehogisanapproximately20kDaproteinexpressedinE.coliconsistingof175aminoacidresidues,includinganN-terminalIle-IlesequencesubstitutedforthenaturallyoccurringchemicallymodifiedCysresidue. |
| AvailableSizes: | 5ug,25ug |
| CatalogNumber: | 12-0009-5,12-0009-25 |
| Source: | EscherichiaColi. |
| Purity: | Greaterthan98%asdeterminedbySDS-PAGE |
| Endotoxin: | Lessthan0.1ng/ug(1EU/ug)ofSHHasdeterminedbytheLALmethod. |
| Storage: | LyophilizedhSHHisstableat-20degreesCto-80degreesCforupto12monthsfromdateofreceipt.hSHHisstableforatleast3monthswhenstoredinworkingaliquotwithacarrierproteinat-20degreesC. |
| Formulation: | Lyophilized(freeze-dried)froma0.22sterile-filteredsolutionin1xPBS&0.1MNaCl. |



